Title

Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents.

Authors

Mei Lu; Qiujun Qiu; Xiang Luo; Xinrong Liu; Jing Sun; Cunyang Wang; Xiangyun Lin; Yihui Deng; Yanzhi Song

Abstract

Although active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholipid complexes represents a promising approach to increase the oral bioavailability of active constituents, which is consist of ''label-friendly" phospholipids and active constituents. Hydrogen bond interactions between active constituents and phospholipids enable phospholipid complexes as an integral part. This review provides an update on four important issues related to phyto-phospholipid complexes: active constituents, phospholipids, solvents, and stoichiometric ratios. We also discuss recent progress in research on the preparation, characterization, structural verification, and increased bioavailability of phyto-phospholipid complexes.

Subjects

BIOAVAILABILITY; HYDROGEN bonding interactions; PHOSPHOLIPIDS

Publication

Asian Journal of Pharmaceutical Sciences, 2019, Vol 14, Issue 3, p265

ISSN

1818-0876

Publication type

Academic Journal

DOI

10.1016/j.ajps.2018.05.011