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- Title
Seroprevalence estimate and risk factors for Coxiella burnetii infections among humans in a highly urbanised Brazilian state.
- Authors
Meurer, Igor Rosa; Silva, Marcio Roberto; Silva, Marcos Vinícius Ferreira; Duré, Ana Íris de Lima; Adelino, Talita Émile Ribeiro; Costa, Alana Vitor Barbosa da; Vanelli, Chislene Pereira; Guimarães, Ricardo José de Paula Souza e; Rozental, Tatiana; Lemos, Elba Regina Sampaio de; Corrêa, José Otávio do Amaral
- Abstract
Background Q fever is among the top 13 global priority zoonoses, however, it is still neglected and under-reported in most of the world, including Brazil. Thus, we evaluated the seroprevalence of and the risk factors for Coxiella burnetii infections in humans from Minas Gerais, a highly urbanised Brazilian state. Methods Coxiella burnetii was searched for patient samples (n=437), which were suspected of then later confirmed as negative for dengue fever, by the indirect immunofluorescence technique and real-time PCR. Risk factors for infections and spatial clusters for both C. burnetii -seropositive individuals and livestock concentration were evaluated. Results We found that 21 samples (4.8%; 95% CI 3.0 to 7.2%) were reactive for at least one class of anti- C. burnetii antibodies (titer of ≥64), with rural residence (p=0.036) being a risk factor. Also, two spatial clusters of seropositivity were found within a significant area by Scan, and a probable relationship between the Scan result and the livestock concentration by area was found. Conclusions Seropositive individuals were associated with rural residence, with a likely relationship with the livestock concentration. Thus, this study establishes baseline figures for C. burnetii seroprevalence in humans in a state of Brazil, allowing the monitoring of trends and setting of control targets, as well as more representative longitudinal and risk analysis studies.
- Subjects
BRAZIL; MINAS Gerais (Brazil); COXIELLA burnetii; Q fever; SEROPREVALENCE; DENGUE; INFECTION; ZOONOSES
- Publication
Transactions of the Royal Society of Tropical Medicine & Hygiene, 2022, Vol 116, Issue 3, p261
- ISSN
0035-9203
- Publication type
Article
- DOI
10.1093/trstmh/trab113