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- Title
Effects of the anaesthetic/tranquillizer treatments on selected plasma biochemical parameters in NZW rabbits.
- Authors
A. González Gil; J. C. Illera; G. Silván; M. Illera
- Abstract
In order to assess the response of plasma biochemical parameters to anaesthesia, 40 New Zealand White (NZW) rabbits were assigned to four treatment groups (n = 10): control (1 ml i.v. saline solution), fentanyl-droperidol (FD) (0.4 ml/kg s.c. of 'thalamonal' solution; 2.5 mg/ml droperidol, 0.05 mg/ml fentanyl), ketamine (K) (10 mg/kg i.v.) with either xylazine (X) (3 mg/kg i.v.) or diazepam (D) (2 mg/kg i.v.). Blood samples were obtained from the central ear artery at six time points: before injection, and at 10, 30, 60, 120 min and 24 h after injection of the anaesthetics/saline. Plasma ALT, AST, ALP, GGT, BUN, creatinine, phosphate and potassium levels were measured by the Hitachi 747 autoanalyser. T he administration of K-X increased (P < 0.05) plasma ALT (from 11.4 ⊥ 0.9 to 20.2 ⊥ 1.7 IU/l, at 10 min), AST (from 10.5 ⊥ 3.3 to 34 ⊥ 2.1 IU/l, at 120 min), BUN (from 17.2 ⊥ 0.9 to 25.8 ⊥ 1.8 mg/dl, at 60 min) and creatinine concentrations (from 1 ⊥ 0.1 to 1.6 ⊥0.2 mg/dl, at 10 min). After K-D administration, we observed an increase (P < 0.05) in plasma ALT (from 11.4 ⊥ 0.9 to 20.2 ⊥ 1.1 IU/l, at 10 min), AST (from 11.4 ⊥ 1.6 to 28 ⊥ 3.7 IU/l, at 10 min), BUN (from 15.8 ⊥ 0.8 to 30 ⊥ 1.5 mg/dl, at 10 min) and creatinine levels (from 1 ⊥ 0.08 to 2.2 ⊥ 0.2 mg/dl, at 120 min). No significant changes were seen in the FD group. We conclude that K-X and K-D may affect plasma concentration of select serum enzymes and biochemical parameters. These results should be taken into account when blood samples are evaluated in treated rabbits.
- Subjects
ANESTHESIA; ANESTHETICS; CREATININE
- Publication
Laboratory Animals, 2003, Vol 37, Issue 2, p155
- ISSN
0023-6772
- Publication type
Article
- DOI
10.1258/00236770360563804