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- Title
CONCLUDING REMARKS.
- Authors
Rylander, Ragnar; Goto, Hajime
- Abstract
The knowledge on 1,3-Β-glucan has increased tremendously since the first glucan workshop in 1990 [1] and a textbook is now available on the toxicity of different forms of 1,3-Β-glucan after different modes of administration [2]. The understanding of the effects of 1,3-Β-glucan is complicated by the many steric forms present and also by the simultaneous presence of other agents in environments where 1,3-Β-glucans are present. Regarding the neutrophil-based acute inflammatory response it seems as if nonwater soluble 1,3-Β-glucan cannot elicit this response whereas water soluble forms and high doses may do so. A major advance in the knowledge has been the identification of a specific receptor and the development of specific antibodies which will facilitate the estimates of exposure both in clinical cases and in the general population. Determinations of 1,3-Β-glucan in serum have become established as a clinical tool in deep mycosis and work is underway to further evaluate the role of 1,3-Β-glucan in pulmonary diseases. A major enigma is still the effect of 1,3-Β-glucan on the immune system after chronic exposure and how this could relate to the risk for allergic sensitization and the suppressive effects on tumor growth seen in some early animal models. Hopefully the proceedings from this glucan workshop will not only point to the importance of 1,3-Β-glucan in the clinical and general environment but also stimulate further research.
- Subjects
GLUCANS
- Publication
Mediators of Inflammation, 2007, Vol 2007, Issue 2, p12
- ISSN
0962-9351
- Publication type
Abstract