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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.
- Published in:
- Journal of Clinical Investigation, 2007, v. 117, n. 1, p. 112, doi. 10.1172/JCI28281
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- Publication type:
- Article
Pharmacological manipulation of Bcl-2 family members to control cell death.
- Published in:
- 2005
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- Publication type:
- journal article
Synergistic interactions with PI3K inhibition that induce apoptosis.
- Published in:
- eLife, 2017, p. 1
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- Publication type:
- Article
Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection.
- Published in:
- eLife, 2017, p. 1, doi. 10.7554/eLife.22509.001
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- Publication type:
- Article
RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.
- Published in:
- Science Signaling, 2014, v. 7, n. 357, p. 1, doi. 10.1126/scisignal.2005301
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- Publication type:
- Article
BH3‐only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α.
- Published in:
- 2021
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- Publication type:
- Correction Notice
Venetoclax with azacitidine or decitabine in patients with newly diagnosed acute myeloid leukemia: Long term follow‐up from a phase 1b study.
- Published in:
- American Journal of Hematology, 2021, v. 96, n. 2, p. 208, doi. 10.1002/ajh.26039
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- Publication type:
- Article
Cristae remodeling causes acidification detected by integrated graphene sensor during mitochondrial outer membrane permeabilization.
- Published in:
- Scientific Reports, 2016, p. 35907, doi. 10.1038/srep35907
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- Publication type:
- Article
Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-38552-z
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- Publication type:
- Article
Comparing syngeneic and autochthonous models of breast cancer to identify tumor immune components that correlate with response to immunotherapy in breast cancer.
- Published in:
- 2021
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- Publication type:
- journal article
Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer.
- Published in:
- 2020
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- Publication type:
- journal article
Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance.
- Published in:
- EMBO Reports, 2018, v. 19, n. 9, p. 1, doi. 10.15252/embr.201745235
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- Publication type:
- Article
Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-019-12477-y
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- Publication type:
- Article
Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling.
- Published in:
- Cancers, 2021, v. 13, n. 5, p. 1002, doi. 10.3390/cancers13051002
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- Publication type:
- Article
BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1?
- Published in:
- EMBO Journal, 2012, v. 31, n. 10, p. 2322, doi. 10.1038/emboj.2012.84
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- Publication type:
- Article
In Conversation with Tony Letai.
- Published in:
- FEBS Journal, 2021, v. 288, n. 21, p. 6087, doi. 10.1111/febs.16229
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- Publication type:
- Article
Priming BCL-2 to kill: the combination therapy of tamoxifen and ABT-199 in ER+ breast cancer.
- Published in:
- 2013
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- Publication type:
- journal article
Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics - recent successes, current challenges and future promise.
- Published in:
- FEBS Journal, 2016, v. 283, n. 19, p. 3523, doi. 10.1111/febs.13714
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- Publication type:
- Article
DNA methyltransferase inhibition overcomes diphthamide pathway deficiencies underlying CD123-targeted treatment resistance.
- Published in:
- 2019
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- Publication type:
- journal article
Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia.
- Published in:
- 2016
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- Publication type:
- journal article
Statins enhance efficacy of venetoclax in blood cancers.
- Published in:
- Science Translational Medicine, 2018, v. 10, n. 445, p. 1, doi. 10.1126/scitranslmed.aaq1240
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- Publication type:
- Article
Overcoming mutational complexity in acute myeloid leukemia by inhibition of critical pathways.
- Published in:
- Science Translational Medicine, 2017, v. 9, n. 413, p. 1, doi. 10.1126/scitranslmed.aao1214
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- Publication type:
- Article
Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis.
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- Science Translational Medicine, 2017, v. 9, n. 420, p. 1, doi. 10.1126/scitranslmed.aal3765
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- Publication type:
- Article
P-089: Identification of novel targets in multiple myeloma for "undruggable" RAS/CDK signaling cascade.
- Published in:
- Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S87, doi. 10.1016/S2152-2650(21)02223-0
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- Publication type:
- Article
Durable Response with Venetoclax in Combination with Decitabine or Azacitidine in Elderly Patients with Acute Myeloid Leukemia (AML).
- Published in:
- Clinical Lymphoma, Myeloma & Leukemia, 2018, v. 18, p. S201, doi. 10.1016/j.clml.2018.07.050
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- Publication type:
- Article
MCL-1 Up-Regulation through MAPK Activation Confers Acquired Resistance to BCL-2 Inhibitor ABT-199 in Pre-Clinical AML Models.
- Published in:
- Clinical Lymphoma, Myeloma & Leukemia, 2017, v. 17, p. S2, doi. 10.1016/j.clml.2017.09.025
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- Publication type:
- Article
BH3 Mimetics May Have Utility in T Cell Non-Hodgkin Lymphomas.
- Published in:
- Clinical Lymphoma, Myeloma & Leukemia, 2017, v. 17, p. S366, doi. 10.1016/j.clml.2017.07.202
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- Publication type:
- Article
Upregulation of MCL-1 through MAPK Activation Maintaining Mitochondrial Oxidative Phosphorylation Confers Acquired Resistance to BCL-2 Inhibitor Venetoclax in AML.
- Published in:
- Clinical Lymphoma, Myeloma & Leukemia, 2017, v. 17, p. S285, doi. 10.1016/j.clml.2017.07.069
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- Publication type:
- Article
A Phase I Trial of a Pharmacodynamically-Conceived Thioguanine/Decitabine Combination in Patients with Advanced Myeloid Malignancies.
- Published in:
- Clinical Lymphoma, Myeloma & Leukemia, 2016, v. 16, p. S24, doi. 10.1016/j.clml.2016.07.035
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- Publication type:
- Article
Metabolomic and BH3 profiling of esophageal cancers: novel assessment methods for precision therapy.
- Published in:
- 2018
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- Publication type:
- journal article
An inhibitor of Bcl-2 family proteins induces regression of solid tumours.
- Published in:
- Nature, 2005, v. 435, n. 7042, p. 677, doi. 10.1038/nature03579
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- Publication type:
- Article
Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.
- Published in:
- Nature, 2003, v. 426, n. 6967, p. 671, doi. 10.1038/nature02067
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- Publication type:
- Article
MCL-1--dependent leukemia cells are more sensitive to chemotherapy than BCL-2--dependent counterparts.
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- Journal of Cell Biology, 2009, v. 187, n. 3, p. 429, doi. 10.1083/jcb.200904049
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- Publication type:
- Article
Puma strikes Bax.
- Published in:
- 2009
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- Publication type:
- Opinion
Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction.
- Published in:
- eLife, 2023, p. 1, doi. 10.7554/eLife.82860
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- Publication type:
- Article
Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells.
- Published in:
- Cell Death & Disease, 2023, v. 14, n. 4, p. 1, doi. 10.1038/s41419-023-05727-x
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- Publication type:
- Article
Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer.
- Published in:
- Cell Death & Disease, 2021, v. 12, n. 8, p. 1, doi. 10.1038/s41419-021-04029-4
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- Publication type:
- Article
Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling.
- Published in:
- Cell Death & Disease, 2019, v. 10, n. 8, p. N.PAG, doi. 10.1038/s41419-019-1801-0
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- Publication type:
- Article
Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics.
- Published in:
- Science Signaling, 2021, v. 14, n. 686, p. 1, doi. 10.1126/scisignal.abc7405
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- Publication type:
- Article
High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors.
- Published in:
- Science Signaling, 2020, v. 13, n. 636, p. 1, doi. 10.1126/scisignal.aay1451
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- Publication type:
- Article
Genetic Bases of Epidermolysis Bullosa Simplex and Epidermolytic Hyperkeratosis.
- Published in:
- Journal of Investigative Dermatology, 1994, v. 103, p. 25S, doi. 10.1038/jid.1994.6
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- Publication type:
- Article
Pancreas-graft immunogenicity and pretreatment with anti-class II monoclonal antibodies.
- Published in:
- 1989
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- Publication type:
- journal article
Increased mitochondrial apoptotic priming with targeted therapy predicts clinical response to re‐induction chemotherapy.
- Published in:
- American Journal of Hematology, 2020, v. 95, n. 3, p. 245, doi. 10.1002/ajh.25692
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- Publication type:
- Article
ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins.
- Published in:
- Cells (2073-4409), 2021, v. 10, n. 7, p. 1659, doi. 10.3390/cells10071659
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- Publication type:
- Article
BCL-X<sub>L</sub> directly modulates RAS signalling to favour cancer cell stemnessa.
- Published in:
- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01079-1
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- Publication type:
- Article
KPT-330 inhibitor of CRM1 ( XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.
- Published in:
- British Journal of Haematology, 2013, v. 161, n. 1, p. 117, doi. 10.1111/bjh.12231
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- Publication type:
- Article
Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release.
- Published in:
- Human Molecular Genetics, 2009, v. 18, n. 22, p. 4317, doi. 10.1093/hmg/ddp384
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- Publication type:
- Article
Comparative analysis of Bcl-2 family protein overexpression in CAR T cells alone and in combination with BH3 mimetics.
- Published in:
- Science Translational Medicine, 2024, v. 16, n. 750, p. 1, doi. 10.1126/scitranslmed.adk7640
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- Publication type:
- Article
iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry.
- Published in:
- Biological Chemistry, 2016, v. 397, n. 7, p. 671, doi. 10.1515/hsz-2016-0107
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- Publication type:
- Article
Diagnosing and exploiting cancer's addiction to blocks in apoptosis.
- Published in:
- Nature Reviews Cancer, 2008, v. 8, n. 2, p. 121, doi. 10.1038/nrc2297
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- Publication type:
- Article