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- Title
Spastic paraparesis and HTLV-I infection in peru.
- Authors
Johnson, Richard T.; Griffin, Diane E.; Arregui, Alberto; Mora, Carlos; Gibbs, Clarence J.; Cuba, Juan M.; Trelles, Luis; Vaisberg, Abraham
- Abstract
Three of 6 patients with spastic paraparesis in Lima, Peru, were found to have antibodies to human T-lymphotropic virus type I (HTLV-I). Blood and cerebrospinal fluid antibodies were confirmed by Western blot analysis. Multilobulated lymphocytes in blood and cerebrospinal fluid of the index case stained with monoclonal antibodies for T-helper cells and for T10, an activation marker. Blood mononuclear cells from patients with HTLV-I-associated myelopathy showed spontaneous proliferation in culture, evidence of interleukin-2 receptors, and decreased natural killer cell activity.
- Publication
Annals of Neurology, 1988, Vol 23, Issue S1, pS151
- ISSN
0364-5134
- Publication type
Article
- DOI
10.1002/ana.410230734