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- Title
Polymorphisms of the MCP-1 and HSP70-2 genes in Korean patients with alcoholic chronic pancreatitis.
- Authors
Lee, Sang Hyub; Ryu, Ji Kon; Jeong, Ji Bong; Lee, Kyeung-Yeup; Woo, Sang Myung; Park, Joo Kyung; Yoo, Ji Won; Kim, Yong-Tae; Yoon, Yong Bum
- Abstract
Alcoholic chronic pancreatitis (ACP) develops in only a small number of alcoholics. Monocyte chemotactic protein-1 (MCP-1) and heat-shock protein 70-2 (HSP70-2) polymorphisms have been reported to be associated with the severity of acute pancreatitis. However, their role in pathogenesis of ACP has not been investigated. A genetic association study for susceptibility and severity was performed on 79 male Korean ACP patients and 82 male controls. MCP-1 and HSP70-2 genotypes were determined using a fluorescence polarization detection method. The genotypes and G allele frequencies were no different in patients and controls. However, MCP-1 G allele had an effect on the development of severe ACP, when its frequency was compared in mild to moderate and severe ACP (29.6 vs. 56.0%, P = 0.02). The MCP-1 and HSP70-2 polymorphisms do not play a major role in the development of ACP in Koreans. However, MCP-1 polymorphism may be associated with the severity of ACP.
- Publication
Digestive Diseases & Sciences, 2008, Vol 53, Issue 6, p1721
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-007-0049-1