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- Title
A common genetic risk factor for colorectal and prostate cancer.
- Authors
Haiman, Christopher A.; Le Marchand, Loïc; Yamamato, Jennifer; Stram, Daniel O.; Xin Sheng; Kolonel, Laurence N.; Wu, Anna H.; Reich, David; Henderson, Brian E.
- Abstract
Variants on chromosome 8q24 contribute risk for prostate cancer; here, we tested whether they also modulate risk for colorectal cancer. We studied 1,807 affected individuals and 5,511 controls and found that one variant, rs6983267, is also significantly associated with colorectal cancer (odds ratio = 1.22; P = 4.4 × 10−6) and that the apportionment of risk among the variants differs significantly between the two cancers. Comprehensive testing in the region uncovered variants capturing significant additional risk. Our results show that variants at 8q24 have different effects on cancer development that depend on the tissue type.
- Subjects
COLON cancer; CANCER genetics; PROSTATE cancer; CANCER risk factors; TUMOR growth; HUMAN chromosomes; CANCER genes
- Publication
Nature Genetics, 2007, Vol 39, Issue 8, p954
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng2098