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- Title
Neutralization of Disease Associated Autoantibodies by An Immunoglobulin M- and Immunoglobulin A-Enriched Human Intravenous Immunoglobulin Preparation.
- Authors
Bar-Dayan; Bonnin; Bloch; Schweitzer; Ravid; Kazatchkine; Kaveri
- Abstract
Immunoglobulin preparations enriched with IgM and IgA are used in the therapy of severe bacterial infections and for the treatment of acute graft-versus-host disease, but not as yet, in the treatment of autoimmune diseases. We investigated the potential of an IgM- and IgA-enriched immunoglobulin preparation to neutralize activity autoantibodies from patients with autoimmune diseases. We demonstrate that Pentaglobin[sup ®] was at least as effective as intravenous immunoglobulin (Sandoglobulin[sup ®]) in inhibiting autoantibody activity. Each of the immunoglobulin isotypes present in Pentaglobin[sup ®] may be responsible for the inhibitory effect. Pentaglobin[sup ®] immobilized on an affinity matrix retained the disease associated autoantibodies and interacted with F(ab′)[sub 2] fragments of IgG autoantibodies. Suppression of autoantibody activity is dependent, at least in part, on idiotypic interactions. The present findings provide a rationale for considering these preparations for the immunomodulation of autoimmune disease.
- Subjects
THERAPEUTIC use of immunoglobulins; AUTOIMMUNE disease treatment
- Publication
Scandinavian Journal of Immunology, 2000, Vol 51, Issue 4, p408
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.2000.00699.x