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- Title
Participation of Vβ4<sup>+</sup>-, V/37<sup>+</sup>-, and V/311+-T Lymphocytes in Haematogenously Acquired Staphylococcus aureus Nephritis.
- Authors
Verba, V.; Tarkowski, A.
- Abstract
The most frequent pathogen in haematogenously acquired kidney infections in humans is <em>Staphylococcus aureus</em>. In order to characterize <em>in situ</em> the immunological patterns of septic nephritis we developed a murine model of this disease. A single intravenous injection of <em>S. aureus</em> producing toxic shock syndrome toxin-1 resulted in high frequency of inflammatory kidney lesions. Histopathologically, both focal and diffuse inflammatory infiltrates were seen in kidney cortex and medulla. Immunohistochemical evaluation revealed high numbers of Mac-1+ phagocytic cells as well as CD4+- and CD8+-lymphocytes. The expansion of lymphocytes carrying T-cell receptor Vβ chain 4, 7, and 11 families in the kidney was observed. Our results suggest that the haematogenously acquired kidney infection by superantigen-producing staphylococci leads to migration, <em>in situ</em> activation and expansion of responding T-lymphocyte subsets.
- Subjects
PATHOGENIC microorganisms; KIDNEY diseases; STAPHYLOCOCCUS aureus; TOXIC shock syndrome; INFLAMMATION; LYMPHOCYTES; T cells; SUPERANTIGENS
- Publication
Scandinavian Journal of Immunology, 1996, Vol 44, Issue 3, p261
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1046/j.1365-3083.1996.d01-309.x