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- Title
Auto- and Polyreactivity of IgM from CD5<sup>+</sup> and CD5<sup>-</sup>Cord Blood B Cells.
- Authors
mackenzie, L. E.; Youinou, P. Y.; Hicks, R.; Yuksel, B.; Mageed, R. A.; Lydyard, P. M.
- Abstract
The presence of the CD5 (67 kDa) molecule on the surface of B cells has been considered a marker for cells producing auto- and polyreactive antibodies. Cord blood B lymphocytes (rich in CD5+ B cells) have been sorted into CD5 positive and negative populations by flow cytometry using monoclonal antibodies to CD20 and CD5. Clones of these populations were obtained by immortalization with Epstein--Barr virus. Clones derived from both CD5+ and CD5- B cells produced IgM which was auto- and polyreactive with a higher frequency of these specificities in the CD5+ population. These data indicate that expression of surface CD5 on cord blood B cells is not a definitive marker of an auto/polyreactive population.
- Subjects
LYMPHOCYTES; B cells; IMMUNOGLOBULINS; CORD blood; LEUCOCYTES; MOLECULAR cloning
- Publication
Scandinavian Journal of Immunology, 1991, Vol 33, Issue 3, p329
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1991.tb01778.x