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- Title
In Vitro Plaque--Forming Cell Responses Induced by <em>Streptococcus pneumoniae</em> in Humans.
- Authors
BeckmAnn, E.; Levitt, D.
- Abstract
When peripheral blood lymphocytes (PBL) were stimulated in vitro with the rough form of type 2 Streptococcus pneumoniae R36a, the resulting plaque-forming cells (PFC) did not produce antibodies directed against phosphorylcholinc, a major antigenic determinant of the cell wall C-polysaccharide, Instead. R36a stimulated polyclonal PFC in PBL and splenic lymphocytes. We compared the polyclonal responses stimulated by R36a with those induced by two well-characterized polyclonal activators (PA), Staphylococcus aureus Cowan 1 and pokeweed mitogen (PWM). We found that R36a was a poor mitogen for PBL, whereas the other two PA were potent mitogens; that the preduminant isotype produced in response to all three PA was IgM; that adherent cells strongly inhibited the polyclonal PFC response to both R36a and Staph, aureus but not PWM; and that T cells were necessary for induction of polyclonal antibody-secreting cells by all three stimuli.
- Subjects
STREPTOCOCCUS pneumoniae; STREPTOCOCCACEAE; STAPHYLOCOCCUS aureus; STAPHYLOCOCCUS aureus infections; LYMPHOCYTES; LEUCOCYTES; EPITOPES
- Publication
Scandinavian Journal of Immunology, 1984, Vol 19, Issue 1, p1
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1984.tb00894.x