We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Thalamocortical Dynamics during Rapid Eye Movement Sleep in the Mouse Somatosensory Pathway.
- Authors
Boscher, Flore; Jumel, Katlyn; Dvořáková, Tereza; Gentet, Luc J.; Urbain, Nadia
- Abstract
Rapid eye movement (REM) sleep, also referred to as paradoxical sleep for the striking resemblance of its electroencephalogram (EEG) to the one observed in wakefulness, is characterized by the occurrence of transient events such as limb twitches or facial and rapid eye movements. Here, we investigated the local activity of the primary somatosensory or barrel cortex (S1) in naturally sleeping head-fixed male mice during REM. Through local field potential recordings, we uncovered local appearances of spindle waves in the barrel cortex during REM concomitant with strong delta power, challenging the view of a wakefulness-like activity in REM. We further performed extra-and intracellular recordings of thalamic cells in head-fixed mice. Our data show highfrequency thalamic bursts of spikes and subthreshold spindle oscillations in approximately half of the neurons of the ventral posterior medial nucleus which further confirmed the thalamic origin of local cortical spindles in S1 in REM. Cortical spindle oscillations were suppressed, while thalamus spike firing increased, associated with rapid mouse whisker movements and S1 cortical activity transitioned to an activated state. During REM, the sensory thalamus and barrel cortex therefore alternate between high (wake-like) and low (non-REM sleep-like) activation states, potentially providing a neuronal substrate for mnemonic processes occurring during this paradoxical sleep stage.
- Subjects
RAPID eye movement sleep; THALAMOCORTICAL system; NON-REM sleep; SLEEP stages; EYE movements; SOMATOSENSORY cortex; MICE
- Publication
Journal of Neuroscience, 2024, Vol 44, Issue 25, p1
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.0158-24.2024