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- Title
Spontaneous regression of congenital leukaemia with an 8;16 translocation.
- Authors
Weintraub, Michael; Kaplinsky, Chaim; Amariglio, Ninette; Rosner, Esther; Brok-Simoni, Frieda; Rechavi, Gideon
- Abstract
Congenital leukaemia (CL) is a rare disorder that presents with extramedullary infiltrates and a myeloid phenotype. CL can progress rapidly without adequate treatment, but, paradoxically, may also remit spontaneously. Because of the significant toxicity involved in delivering chemotherapy to newborns, it is important to identify those newborns who may not require treatment. We describe an infant who presented at 1 week of age with congenital myeloid leukaemia. Cytogenetic analysis revealed a t(8;16)(q11;p13) translocation. The infant's leukaemia underwent a spontaneous regression. This case further confirms the possibility of spontaneous remission in congenital leukaemia. Moreover, it suggests that the presence of a clonal cytogenetic aberration does not preclude the possibility of a spontaneous regression in CL.
- Subjects
LEUKEMIA; REGRESSION analysis; CHROMOSOMAL translocation; CYTOGENETICISTS
- Publication
British Journal of Haematology, 2000, Vol 111, Issue 2, p641
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2000.02356.x