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- Title
D<sub>1</sub>- and D<sub>2</sub>-like receptors differentially mediate the effects of dopaminergic transmission on cost–benefit evaluation and motivation in monkeys.
- Authors
Hori, Yukiko; Nagai, Yuji; Mimura, Koki; Suhara, Tetsuya; Higuchi, Makoto; Bouret, Sebastien; Minamimoto, Takafumi
- Abstract
It has been widely accepted that dopamine (DA) plays a major role in motivation, yet the specific contribution of DA signaling at D1-like receptor (D1R) and D2-like receptor (D2R) to cost–benefit trade-off remains unclear. Here, by combining pharmacological manipulation of DA receptors (DARs) and positron emission tomography (PET) imaging, we assessed the relationship between the degree of D1R/D2R blockade and changes in benefit- and cost-based motivation for goal-directed behavior of macaque monkeys. We found that the degree of blockade of either D1R or D2R was associated with a reduction of the positive impact of reward amount and increasing delay discounting. Workload discounting was selectively increased by D2R antagonism. In addition, blocking both D1R and D2R had a synergistic effect on delay discounting but an antagonist effect on workload discounting. These results provide fundamental insight into the distinct mechanisms of DA action in the regulation of the benefit- and cost-based motivation, which have important implications for motivational alterations in both neurological and psychiatric disorders. Using quantitatively controlled pharmacological manipulations, this study teases apart the role of D1- and D2-like dopamine receptors in motivation and goal-directed behavior in monkeys, revealing complementary roles of two dopamine receptor subtypes in the computation of the cost/benefit trade-off to guide action.
- Subjects
DOPAMINE receptors; ACTION theory (Psychology); DELAY discounting (Psychology); POSITRON emission tomography; MONKEYS; MOTIVATION (Psychology)
- Publication
PLoS Biology, 2021, Vol 19, Issue 6, p1
- ISSN
1544-9173
- Publication type
Article
- DOI
10.1371/journal.pbio.3001055