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- Title
Study of the Risk and Preventive Factors for Progress of Mild Cognitive Impairment to Dementia.
- Authors
Hu, Chengping; Wang, Ling; Guo, Yi; Cao, Zhicheng; Lu, Ying; Qin, Hongyun
- Abstract
Objective: To evaluate the risk factors for progress of mild cognitive impairment to dementia. Methods: This study was based on the epidemiological survey in 2011 (No. PKJ2010-Y26) and contained 441 MCI individuals. Cognitive function was measured by the Mini-Mental Status Examination, clinical dementia rating, and montreal cognitive assessment. The association between demographic characteristics and MCI outcomes were evaluated using single-and multifactor ordered logistic regression analysis models. Results: Of the 441 MCI, 77 progressed to dementia (MCIp: 17.5%, 95% CI: 14.4%-21.6%), 356 remained stable (MCIs: 80.7%, 95% CI: 77.0%-88.4%), and 8 reverted to normal cognition (MCIr: 1.8%, 95% CI: 0.6%-3.0%) at follow-up in 2017. Univariate ordinal regression analysis showed that diabetes (P =.052), marriage (P =.028), worker (P =.069), and manager (P =.075) may be the risk factor for the status of MCI. Multiple ordinal regression results showed that diabetes (P =.049) and marriage (P =.04) significantly affected the cognitive function changes in the MCI patients. Conclusion: Nondiabetics and being married may prevent the progression from MCI to dementia.
- Subjects
DEMENTIA prevention; DEMENTIA risk factors; DIABETES complications; COGNITION; COGNITION disorders; CONFIDENCE intervals; EMPLOYMENT; LIFE skills; MARITAL status; PSYCHOLOGICAL tests; LOGISTIC regression analysis; EDUCATIONAL attainment; DISEASE progression; DESCRIPTIVE statistics
- Publication
American Journal of Alzheimer's Disease & Other Dementias, 2020, Vol 35, p1
- ISSN
1533-3175
- Publication type
Article
- DOI
10.1177/1533317520925324