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- Title
IL-10 Augments Antibody Production in in Vitro Immunized Lymphocytes by Inducing a Th2-Type Response and B Cell Maturation.
- Authors
Qianghua Xu; Katakura, Yoshinori; Yamashita, Makiko; Shengguo Fang; Tamura, Takashi; Matsumoto, Shin-ei; Aiba, Yoshihiro; Teruya, Kiichiro; Osada, Kazuhiro; Nishikawa, Ryuhei; Shirahata, Sanetaka
- Abstract
Reports on the findings that IL-10 augments antibody production in vitro immunized lymphocytes by inducing a Th2-type response and B cell maturation. Demonstration of the role of IL-10 in the augmentation of the antibody production in an IVI protocol by clarifying the cytokine expression profiles in CD4+ and CD8+ T cells; Results that showed the process IL-10 skewed the Th1/Th2 balance to Th2-type responses; Findings that indicate IL-10 plays an important role in setting the cellular milieu to produce antibodies in an IVI protocol.
- Subjects
IMMUNOGLOBULINS; B cells; LYMPHOCYTES; IMMUNIZATION; LIFE sciences; BIOTECHNOLOGY; BIOCHEMISTRY
- Publication
Bioscience, Biotechnology & Biochemistry, 2004, Vol 68, Issue 11, p2279
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.68.2279