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- Title
Cytotoxicity and DNA Topoisomerase Inhibitory Activity of Benz[f]indole-4,9-dione Analogs.
- Authors
Hyen Joo Park, Morio; Hyun-Jung Lee; Eun-Jin Lee; Hye-Jin Hwang, Morio; Sang-Hee Shin, Morio; Myung-Eun Suh, Morio; Choonmi Kim, Morio; Hwa Jung Kim, Morio; Eun-Kyung Seo, Morio; Sang Kook Lee
- Abstract
Evaluates the cytotoxicity and DNA topoisomerase inhibitory activity of benz[f]indole-4,9-dione analogs, based on the antitumor activity of 1,4,-naphthoquinone. Cytotoxic activity in human lung carcinoma, colon carcinoma and stomach carcinoma; Potent inhibitory activity; Selective inhibitory activity against topoisomerase I compared to topoisomerase II.
- Subjects
ANTINEOPLASTIC agents; NAPHTHOQUINONE; DNA topoisomerase I; DNA topoisomerase II
- Publication
Bioscience, Biotechnology & Biochemistry, 2003, Vol 67, Issue 9, p1944
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.67.1944