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- Title
Intestinal immunostimulatory activity of neutral polysaccharide isolated from traditionally fermented Korean brown rice vinegar.
- Authors
Kim, Hoon; Lee, Ho; Shin, Kwang-Soon
- Abstract
In this study, diverse intestinal immunostimulatory activities were demonstrated for polysaccharides (KBV-CP) isolated from Korean brown rice vinegar. Monosaccharide composition analysis indicated that KBV-CP was composed mainly of neutral sugar units, primarily glucose and mannose.In vitro, KBV-CP significantly augmented the productions of immunoglobulin A (IgA) and IgA-related cytokines such as interleukin-6 (IL-6) and transforming growth factor-β (TGF-β) in a dose-dependent manner. Furthermore, results of anin vitroco-culture system of intestinal Caco-2 cells and RAW 264.7 macrophage cells suggested that KBV-CP is not only cytotoxic to Caco-2 cells but also capable of being transported across the small intestinal barrier. Oral administration of KBV-CP every other day for 20 days induced the IgA production by Peyer’s patch cells as well as in intestinal fluid and fecal extract. In addition, the production of IgA-related cytokines such as TGF-β and IL-6, and granulocyte macrophage colony-stimulating factor was triggered. In vitroandin vivoexperiments for evaluation of KBV-CP on the intestinal immune system.
- Subjects
RICE vinegar; POLYSACCHARIDES; PEYER'S patches
- Publication
Bioscience, Biotechnology & Biochemistry, 2016, Vol 80, Issue 12, p2383
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2016.1217149