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- Title
Toward noninvasive assessment of flap viability with time-resolved diffuse optical tomography: a preclinical test on rats.
- Authors
Di Sieno, Laura; Bettega, Georges; Berger, Michel; Hamou, Cynthia; Aribert, Marion; Mora, Alberto Dalla; Puszka, Agathe; Grateau, Henri; Contini, Davide; Hervé, Lionel; Coll, Jean-Luc; Dinten, Jean-Marc; Pifferi, Antonio; Planat-Chrétien, Anne
- Abstract
The noninvasive assessment of flap viability in autologous reconstruction surgery is still an unmet clinical need. To cope with this problem, we developed a proof-of-principle fully automatized setup for fast timegated diffuse optical tomography exploiting Mellin-Laplace transform to obtain three-dimensional tomographic reconstructions of oxy- and deoxy-hemoglobin concentrations. We applied this method to perform preclinical tests on rats inducing total venous occlusion in the cutaneous abdominal flaps. Notwithstanding the use of just four source-detector couples, we could detect a spatially localized increase of deoxyhemoglobin following the occlusion (up to 550 µM in 54 min). Such capability to image spatio-temporal evolution of blood perfusion is a key issue for the noninvasive monitoring of flap viability.
- Subjects
NONINVASIVE diagnostic tests; OPTICAL coherence tomography; LAPLACE transformation; SURGICAL flaps; LABORATORY rats
- Publication
Journal of Biomedical Optics, 2016, Vol 21, Issue 2, p1
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.JBO.21.2.025004