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- Title
Statistical analysis of motion contrast in optical coherence tomography angiography.
- Authors
Yuxuan Cheng; Li Guo; Cong Pan; Tongtong Lu; Tianyu Hong; Zhihua Ding; Peng Li
- Abstract
Optical coherence tomography angiography (Angio-OCT), mainly based on the temporal dynamics of OCT scattering signals, has found a range of potential applications in clinical and scientific research. Based on the model of random phasor sums, temporal statistics of the complex-valued OCT signals are mathematically described. Statistical distributions of the amplitude differential and complex differential Angio-OCT signals are derived. The theories are validated through the flow phantom and live animal experiments. Using the model developed, the origin of the motion contrast in Angio-OCT is mathematically explained, and the implications in the improvement of motion contrast are further discussed, including threshold determination and its residual classification error, averaging method, and scanning protocol. The proposed mathematical model of Angio-OCT signals can aid in the optimal design of the system and associated algorithms.
- Subjects
OPTICAL coherence tomography; ANGIOGRAPHY; CONTRAST media; IMAGING phantoms; STATISTICS
- Publication
Journal of Biomedical Optics, 2015, Vol 20, Issue 11, p116004-1
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.JBO.20.11.116004