Two new sesquiterpenes, named 9-methoxymyrrhone ( 1) and rel-(1 S,2 S,3 R,4 S) -1,2-epoxy-3-methoxyfuranogermacr-10(15)-en-6-one ( 2), together with nine known compounds ( 3- 11), were isolated from the resin of Commiphora opobalsamum. The structures were established by HR-ESI-MS, 1D-, and 2D-NMR spectroscopic analyses.