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- Title
One-Pot Synthesis of 5,7,8,9,9a,10-Hexahydro-8-thioxotetrahydropyrido[2,3- d : 6,5- d′]dipyrimidine-2,4,6(1 H,3 H,5a H)-triones via a Four-Component Coupling Reaction of Aldehydes, Amines, Barbituric Acids, and Thiouracil.
- Authors
Khalafi-Nezhad, Ali; Panahi, Farhad; Golesorkhi, Bahman
- Abstract
An efficient one-pot approach to the synthesis of 5,7,8,9,9a,10-hexahydro-8-thioxopyrido[2,3- d : 6,5- d′]dipyrimidine-2,4,6(1 H,3 H,5a H)-triones 5 via a four-component reaction of an aldehyde 1, an amine 2, a barbituric acid 3, and thiouracil ( 4) is reported for the first time. This new multicomponent reaction is accomplished in refluxing EtOH in the presence of tungstophosphoric acid (H3PW12O40) as a catalyst. A variety of hexahydropyrido[2,3- d : 6,5- d′]dipyrimidinetrione derivatives were successfully synthesized in excellent yields with this protocol ( Table 2).
- Subjects
THIOURACIL; ALDEHYDES; AMINES; ORGANIC synthesis; CHEMICALS
- Publication
Helvetica Chimica Acta, 2013, Vol 96, Issue 6, p1155
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.201200350