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- Title
Transit time corrected arterial spin labeling technique aids to overcome delayed transit time effect.
- Authors
Yun, Tae Jin; Sohn, Chul-Ho; Yoo, Roh-Eul; Kang, Kyung Mi; Choi, Seung Hong; Kim, Ji-hoon; Park, Sun-Won; Hwang, Moonjung; Lebel, R. Marc
- Abstract
Purpose: This study aimed to evaluate the usefulness of transit time corrected cerebral blood flow (CBF) maps based on multi-phase arterial spin labeling MR perfusion imaging (ASL-MRP).Methods: The Institutional Review Board of our hospital approved this retrospective study. Written informed consent was waived. Conventional and multi-phase ASL-MRPs and dynamic susceptibility contrast MR perfusion imaging (DSC-MRP) were acquired for 108 consecutive patients. Vascular territory-based volumes of interest were applied to CBF and time to peak (TTP) maps obtained from DSC-MRP and CBF maps obtained from conventional and multi-phase ASL-MRPs. The concordances between normalized CBF (nCBF) from DSC-MRP and nCBF from conventional and transition time corrected CBF maps from multi-phase ASL-MRP were evaluated using Bland-Altman analysis. In addition, the dependence of difference between nCBF (ΔnCBF) values obtained from DSC-MRP and conventional ASL-MRP (or multi-phase ASL-MRP) on TTP obtained from DSC-MRP was also analyzed using regression analysis.Results: The values of nCBFs from conventional and multi-phase ASL-MRPs had lower values than nCBF based on DSC-MRP (mean differences, 0.08 and 0.07, respectively). The values of ΔnCBF were dependent on TTP values from conventional ASL-MRP technique (<italic>F</italic> = 5.5679, <italic>P</italic> = 0.0384). No dependency of ΔnCBF on TTP values from multi-phase ASL-MRP technique was revealed (<italic>F</italic> = 0.1433, <italic>P</italic> > 0.05).Conclusion: The use of transit time corrected CBF maps based on multi-phase ASL-MRP technique can overcome the effect of delayed transit time on perfusion maps based on conventional ASL-MRP.
- Subjects
BRAIN mapping; CEREBRAL circulation; HEMODYNAMICS; MAGNETIC resonance imaging; PERFUSION; RADIONUCLIDE imaging; REGRESSION analysis; RETROSPECTIVE studies
- Publication
Neuroradiology, 2018, Vol 60, Issue 3, p255
- ISSN
0028-3940
- Publication type
Article
- DOI
10.1007/s00234-017-1969-x