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- Title
Underexpression of miR-126 and miR-20b in Hereditary and Nonhereditary Colorectal Tumors.
- Authors
Yamaguchi, Tatsuro; Iijima, Takeru; Wakaume, Rika; Takahashi, Keiichi; Matsumoto, Hiroshi; Nakano, Daisuke; Nakayama, Yujiro; Mori, Takeo; Horiguchi, Shinichiro; Miyaki, Michiko
- Abstract
Objectives: The aim of the study was to determine the significance of miR-126 and miR-20b in colorectal carcinogenesis. Methods: We analyzed the expressions of miR-126 and miR-20b in 136 colorectal tumors from 39 microsatellite stable (MSS) tumors, 23 high microsatellite instability (MSI-H) tumors, 16 Lynch syndrome, and 58 familial adenomatous polyposis (FAP) tumors including adenoma, intramucosal carcinoma, and invasive carcinoma. Results: All four kinds of tumors showed underexpression of both miR-126 and miR-20b. The frequency of miR-126 downregulation was 100.0% in FAP adenomas, 85.7% in FAP intramucosal carcinomas, 78.9% in invasive carcinomas, 81.3% in Lynch syndrome tumors, 68.4% in MSS tumors, and 65.4% in MSI-H tumors. The frequency of miR-20b downregulation was 64.0% in FAP adenomas, 50.0% in FAP intramucosal carcinomas, 73.3% in invasive carcinomas, 62.5% in Lynch syndrome tumors, 79.5% in MSS tumors, and 91.3% in MSI-H tumors. The current study demonstrated underexpression of miR-126 and miR-20b in various types of colorectal cancer. These findings support the hypothesis that angiogenesis results from underexpressions of miR-126 and miR-20b and occurs as an early event in colorectal carcinogenesis. Conclusions: Underexpression of miR-126 and miR-20b was observed in various types of colorectal cancer, and occurs as an early event of colorectal carcinogenesis in FAP tumors. © 2014 S. Karger AG, Basel
- Subjects
JAPAN; ACADEMIC medical centers; ANALYSIS of variance; COLON tumors; STATISTICAL correlation; POLYMERASE chain reaction; RECTUM tumors; RESEARCH funding; STATISTICS; TUMOR markers; DATA analysis; VASCULAR endothelial growth factors
- Publication
Oncology, 2014, Vol 87, Issue 1, p58
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000363303