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- Title
Association Between Glutathione S-transferase P1, T1 and M1 Genetic Polymorphisms and Response and Survival of Patients with Neoadjuvant Treated Locally Advanced Gastric Cancer.
- Authors
Ott, K.; Vogelsang, H.; Becker, K.; Doring, C.; Kolbl, M.; Fink, U.; Dittler, H.; Lordick, F.; Hofler, H.; Siewert, J. R.; Keller, G.
- Abstract
Response to chemotherapy and patient's survival is likely to be predicted by a number of tumor tissue dependent characteristics as well as by constitutional factors. Glutathione S-transferase (GST) enzymes detoxify therapeutic drugs and reactive oxidants, so that GST polymorphisms may influence response to chemotherapy and survival. GSTTl and GSTPl polymorphisms are neither associated with response nor with prognosis in locally advanced neoadjuvant treated gastric cancer. GSTMl shows no correlation with response as well. However completely resected patients with the GSTMl present genotype have a significant improved survival compared to the GSTMl null genotype.
- Subjects
GENETIC polymorphisms; PHARMACOLOGY; CANCER patients; THERAPEUTICS; DRUG therapy; GLUTATHIONE; TRANSFERASES
- Publication
European Surgical Research, 2004, Vol 36, p59
- ISSN
0014-312X
- Publication type
Article