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- Title
Migrastatin, Isomigrastatin and Their Analogues Isolated from Streptomyces ardus.
- Authors
Chen, Xiao; Li, Qin-Yuan; Zhao, Yang; Miao, Cui-Ping; Zhao, Li-Xing; Jiang, Cheng-lin; Wu, Shao-Hua; Li, Yi-Qing
- Abstract
Compound B 3 b exhibited antifungal activity against I F. solani i at MIC 64 g/mL; compound B 4 b exhibited antifungal activity against I A. panax i and I F. solani i at MICs of 32 and 64 g/mL, respectively. Subfraction 2.1 was separated by semipreparative reverse-phase HPLC using CH SB 3 sb CN-H SB 2 sb O, from 20:80 to 80:20 as the mobile phase to yield compounds B 1 b (5 mg), B 3 b (15 mg), and B 4 b (10 mg). The results indicated that among the test compounds B 1-5 b , compound B 1 b exhibited antifungal activity against I F. solani i at the MIC 64 g/mL; compound B 2 b displayed antifungal activity against I P. cucumerina i , I F. oxysporum i , I F. solani i , and I A. panax i at MICs of 32, 64, 64 and 64 g/mL, respectively.
- Subjects
STREPTOMYCES; GRADIENT elution (Chromatography); NORMAL-phase chromatography; COUNTERCURRENT chromatography
- Publication
Chemistry of Natural Compounds, 2023, Vol 59, Issue 5, p900
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-023-04145-x