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- Title
Determinants of the duration of B-cell depletion after rituximab in a pediatric population.
- Authors
Affes, Rayan; Lapeyraque, Anne-Laure; Laroche, Camille; Labrosse, Roxane; Cambier, Alexandra; Demers, Emile; Flahault, Adrien
- Abstract
This article explores the duration of B-cell depletion in pediatric patients undergoing rituximab therapy for various nephrological conditions. The study reveals that the duration of B-cell depletion varies among individuals and that predicting this duration could enhance treatment effectiveness. Factors such as higher doses of rituximab and concomitant use of mycophenolate mofetil were associated with longer B-cell depletion. Additionally, a longer duration of B-cell depletion was linked to a potential decrease in the risk of clinical relapse in patients with nephrotic syndrome. The study emphasizes the importance of understanding the factors influencing B-cell depletion duration to optimize rituximab treatment. However, the study acknowledges limitations, including the lack of standardized immunophenotyping times and a relatively small number of patients using mycophenolate mofetil. Further research is needed to explore the relationship between mycophenolate mofetil and the risk of relapse in steroid-dependent nephrotic syndrome.
- Subjects
CHILD patients; RITUXIMAB; MYCOPHENOLIC acid; NEPHROTIC syndrome; DISEASE relapse
- Publication
Nephrology Dialysis Transplantation, 2024, Vol 39, Issue 1, p159
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfad147