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- Title
Does alcohol consumption modify the risk of endometrial cancer? A dose-response meta-analysis of prospective studies.
- Authors
Zhou, Quan; Guo, Peng; Li, Hui; Chen, Xiao-dan
- Abstract
<bold>Background: </bold>Epidemiological studies have provided controversial evidence of an association between alcohol intake and endometrial cancer (EC) risk. The World Cancer Research Fund/American Institute for Cancer Research classifies alcohol as having a "limited-no conclusion" grade of evidence in the Endometrial Cancer 2013 Report (the latest version).<bold>Objective: </bold>The purpose of this meta-analysis is to systematically analyze the effect of alcohol intake on EC risk.<bold>Methods: </bold>We conducted a dose-response meta-analysis of prospective cohort studies identified from the PubMed, Embase, Cochrane Library and China Biological Medicine databases. Categorical and dose-response meta-analyses were conducted to estimate the effects of alcohol on EC risk.<bold>Results: </bold>A total of 10 studies involving 9766 cases and 1,612,798 participants were included in this meta-analysis. Overall, the relative risk(RR) for alcohol intake on EC was 1.04 (95% CI 0.88-1.22). The RRs for alcohol intake from wine, beer, and liquor were 1.10 (95% CI 0.80-1.51), 0.94 (95% CI 0.72-1.22), and 1.04 (95% CI 0.86-1.27), respectively). When alcohol consumption was stratified by drinking level, the RRs for moderate and heavy alcohol intake were 0.95 (95% CI 0.89-1.01) and 1.00 (95% CI 0.88-1.13), respectively. In the subgroup analyses, this association was not modified by other lifestyle factors or the characteristics of the study design and population. No significant associations were detected in the dose-response meta-analyses.<bold>Conclusions: </bold>Alcohol intake is not associated with EC regardless of the beverage choice and alcohol consumption level. More studies are warranted in other populations, such as Asians and Africans.
- Subjects
ENDOMETRIAL cancer risk factors; ALCOHOL drinking &; health; EPIDEMIOLOGY of cancer; DOSE-response relationship in biochemistry; SYSTEMATIC reviews
- Publication
Archives of Gynecology & Obstetrics, 2017, Vol 295, Issue 2, p467
- ISSN
0932-0067
- Publication type
journal article
- DOI
10.1007/s00404-016-4263-y