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- Title
Multidirectional chromosome painting reveals a remarkable syntenic homology between the greater galagos and the slow loris<FNR></FNR><FN>This article is a US government work, and, as such, is in the public domain in the United States of America. </FN>.
- Authors
Stanyon, R.; Dumas, F.; Stone, G.; Bigoni, F.
- Abstract
We report on the first reciprocal chromosome painting of lorisoids and humans. The chromosome painting showed a remarkable syntenic homology between Otolemur and Nycticebus. Eight derived syntenic associations of human segments are common to both Otolemur and Nycticebus, indicative of a considerable period of common evolution between the greater galago and the slow loris. Five additional Robertsonian translocations form the slow loris karyotype, while the remaining chromosomes are syntenically equivalent, although some differ in terms of centromere position and heterochromatin additions. Strikingly, the breakpoints of the human chromosomes found fragmented in these two species are apparently identical. Only fissions of homologs to human chromosomes 1 and 15 provide significant evidence of a cytogenetic link between Lemuriformes and Lorisiformes. The association of human chromosomes 7/16 in both lorisoids strongly suggests that this chromosome was present in the ancestral primate genome. Am. J. Primatol. 68:349–359, 2006. © 2006 Wiley-Liss, Inc.
- Subjects
CHROMOSOMES; GALAGOS; LORIS (Genus); KARYOTYPES; HUMAN chromosomes
- Publication
American Journal of Primatology, 2006, Vol 68, Issue 4, p349
- ISSN
0275-2565
- Publication type
Article
- DOI
10.1002/ajp.20229