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- Title
METABOLISM OF AROMATIC NITRO COMPOUNDS 2. EXCRETION OF DIAZOTISABLE AMINES IN THE URINE AFTER INTAKE OF T.N.T. AND OF REDUCTION PRODUCTS OF T.N.T.
- Authors
Lemberg, R.; Callaghan, J. P.
- Abstract
The excretion of diazotisable aromatic amino compounds in the urine of rats and men is always roughly proportional to the intake of T.N.T., and remains constant in rats until the day of death. About 20 per cent, of a single dose of T.N.T. given per os to rats can be recovered in the urine of rats as diazotisable amine. Most of this is execreted on the first day, but smaller amounts continue to be excreted for several days afterwards. If the dose is repeated, the initial response after the later doses is the same, hut the level of slow gradual excretion of diazotisable compounds is increased after each dose. On continuous dosing with T.N.T. 10-15 per cent, is excreted as diazotisable amines in the urine, and the experiments indicate again some storage. Nevertheless no direct evidence for such storage, either in the form of unaltered T.N.T. or as aromatic amino compounds, could be detected. Continuous dosing of T.N.T. through the skin causes the same average excretion of aromatic amines as ingestion. No diazotisable amine is execreted in the faeces. Human volunteers excreted on the average 44 per cent, of small doses of ingested T.N.T. as aromatic amino compounds in the urine. While the ingestion of 4-azoxy--2.6-dinitrotoluene by rats does not lead to an appreciable excretion of aromatic amines in the urine, 4-hydroxylamino--2.6-di-nitrotoluene and 4-amino--2.6-dinitrotoluene cause excretion to the same extent as T.N.T., and 2.4-diamino--6-nitrotoluene to a slightly higher extent. The loss of T.N.T. is therefore largely due to the destruction of its reduction products in the body.
- Subjects
AMINO compounds; AROMATIC compounds; URINE; AMINES; ORGANIC compounds; METABOLISM
- Publication
Australian Journal of Experimental Biology & Medical Science, 1945, Vol 23, Issue 1, p6
- ISSN
0004-945X
- Publication type
Article
- DOI
10.1038/icb.1945.2