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- Title
Synthesis, characterization and biological evaluation of some novel sulfonylurea derivatives.
- Authors
TOK, Fatih; CİHANGİR, Hümeyra; ŞAN, Kader; ÇAKIR, Cansel; TUNA, Kübra; SICAK, Yusuf; ÖZTÜRK, Mehmet; KOÇYİĞİT-KAYMAKÇIOĞLU, Bedia
- Abstract
In this study, some new sulfonylurea derivatives based on the sulfanilamide compound were synthesized. IR, 1H-NMR, 13C-NMR spectroscopic methods and elemental analysis data were used to confirm the structures of the synthesized compounds. ABTS, DPPH, Cuprac and β-Carotene/linoleic acid assays were performed to evaluate the antioxidant activities of sulphonylurea derivatives. The activities of these compounds against some enzymes (acetylcholinesterase, butrylcholinesterase, tyrosinase, α-amylase and α-glucosidase) were also investigated. Compounds S7, S8, S13 and S14 showed inhibitory activity against α-amylase enzyme with IC50 values of 227.84±1.48- 298.27±8.61 µM. In addition, the drug-likeness properties and solubility of the compounds were determined by computational programs.
- Subjects
SULFONYLUREAS; CHEMICAL synthesis; PHENOL oxidase; ELEMENTAL analysis; AMYLOLYSIS; ACETYLCHOLINESTERASE; DRUG solubility
- Publication
Journal of Research in Pharmacy, 2023, Vol 27, Issue 6, p2416
- ISSN
2630-6344
- Publication type
Article
- DOI
10.29228/jrp.529