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- Title
Synthesis, structure elucidation and cytotoxic activities of 2,5-disubstituted-1,3,4-thiadiazole and l,2,4-triazole-3- thione derivatives.
- Authors
KANDEMİR, Levent; KARAKUŞ, Sevgi; ÖZBAŞ, Suna; ROLLAS, Sevim; AKBUĞA, Julide
- Abstract
In this study, a series of 1,3,4-thiadiazole (1b-9b) and l,2,4-triazole-3-thione (1c-9c) derivatives were synthesized. The reaction proses was carried out with the cyclocondensation of suitable 1,4-disubstituted thiosemicarbazide derivatives (1a-9a). The structures of the synthesized compounds were confirmed by the data obtained from elemental analysis, HPLC, UV, IR, 1H-NMR and MS spectra. All of the compounds were tested for their cytotoxic activities against L929 fibroblast cells by MTT method. It was determined that the tested compounds 1a-9a, 1b-9b and 1c-9c were not cytotoxic at the studied concentrations (5.0 µg/mL and 10.0 µg/mL) in L929 cell lines. Compounds 1a-c, 2a-c, 3a-c, 4a-c, 5a-c and 8a-c showed increased growth inhibition whereas compounds 6a-c, 7a-c and 9a-c showed decreased growth inhibition on L929 cell lines.
- Subjects
THIADIAZOLES; CELL lines; ELEMENTAL analysis; CHEMICAL synthesis; FIBROBLASTS; HIGH performance liquid chromatography
- Publication
Journal of Research in Pharmacy, 2022, Vol 26, Issue 4, p941
- ISSN
2630-6344
- Publication type
Article
- DOI
10.29228/jrp.192