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- Title
The Inhibitory Activity of Lactobacillus plantarum Supernatant against Enterobacteria, Campylobacter, and Tumor Cells.
- Authors
Danilova, T. A.; Adzhieva, A. A.; Mezentseva, M. V.; Suetina, I. A.; Danilina, G. A.; Minko, A. G.; Dmitrieva, M. L.; Zhukhovitsky, V. G.
- Abstract
Cell-free supernatant of Lactobacillus plantarum exhibit a strong antimicrobial effect against a number of pathogenic enterobacteria (E. coli, Shigella flexneri, Salmonella typhimurium, Proteus mirabilis, and Campylobacter jejuni). The degree of growth inhibition in broth culture reached a high level for all tested bacteria. The highest rates were noted for P. mirabilis (by 13 times) and the lowest for S. flexneri (by 5 times) and C. jejuni (by 4.5 times). Significant antiproliferative effect of the supernatant on cells of tumor-derived epithelial cell lines was shown. The highest degree of inhibition (by 22 times) was observed for HT-29 cells (colon carcinoma). Thus, inclusion of probiotics in traditional treatment schemes can increase the effectiveness of antibacterial and antitumor drug therapy.
- Subjects
ENTEROBACTERIACEAE; CAMPYLOBACTER; INHIBITION (Chemistry); ESCHERICHIA coli; SHIGELLA flexneri; LACTOBACILLUS plantarum; CAMPYLOBACTER jejuni
- Publication
Bulletin of Experimental Biology & Medicine, 2023, Vol 176, Issue 1, p64
- ISSN
0007-4888
- Publication type
Article
- DOI
10.1007/s10517-023-05969-x