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- Title
高温响应因子A1 活化转化生长因子 β1 促瘢痕疙瘩发病的研究.
- Authors
金石峰; 郭澍; 徐冬冬; 陈柏宇
- Abstract
Objective To explore the role of HTRA1 in the pathogenesis of keloids. Methods The expression of HTRA1 was detected by real time PCR, Western blot and immunohistochemistry. The dynamic changes of TGF-β1 activity were measured by luciferase reporting assay. Results Compared to normal skin, the expression of HTRA1 and TGF-β1 in keloids was significantly elevated. Co-culture with recombinant human HTRA1 (rhHTRA1) significantly increased the activation level of TGF-β1 and the phosphorylation level of Smad2. Conclusion HTRA1 was involved in the pathogenesis of keloids through regulating the activation of latent TGF-β1 in keloid fibroblasts. Therefore, HTRA1 can promote the development of keloids.
- Publication
Chinese Journal of Aesthetic & Plastic Surgery, 2019, Vol 30, Issue 5, p310
- ISSN
1673-7040
- Publication type
Article
- DOI
10.3969/j.issn.1673-7040.2019.05.017