We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
黄芪 桂 枝 五 物 汤 对 缓 慢 性 心 律 失 常 患 者 心 率 恢复、血清脂肪酸结合蛋白及血浆 AngⅡ、Adropin、Gal-3 的影响.
- Authors
张成成; 王 娜; 王庆凯
- Abstract
OBJECTIVE: To probe into the effects of Huangqi Guizhi Wuwu decoction on heart rate recovery from bradyarrhythmia, serum fatty acid binding protein levels and plasma Ang Ⅱ, Adropin and galectin (Gal) 3. METHODS: A total of 120 patients with bradyarrhythmias admitted into the hospital from Apr. 2020 to Apr. 2021 were extracted to be divided into the control group and the observation group via the random number table method, with 60 cases in each group. The control group was treated with routine treatment, while the observation group received Huangqi Guizhi Wuwu decoction based on the control group. The levels of Gal-3, vasoactive intestinal peptide (VIP), nitric oxide (NO) and Ang Ⅱ, Adropin, growth differentiation factor (GDF)-15, creatine kinase isoenzyme (CK-MB), heart-type fatty acid binding protein (H-FABP), endogenous nociceptin / orphanin FQ (N/ OFQ), left ventricular ejection fraction (LVEF), heart rate (HR), root mean square of the difference between successive NN intervals (RMSSD), every 5 min NN standard deviation of mean interval (SDANN) and total NN interval (SDNN) before and after treatment in two groups were detected. Clinical efficacy of two groups were compared. RESULTS: After treatment, the level of Ang Ⅱ of the observation group was lower than that of the control group, the levels of VIP, Adropin and NO were higher than those of the control group, the levels of Gal-3, GDF-15 was lower than that of the control group, the levels of H-FABP, CK-MB and N/ OFQ were lower than those of the control group, the levels of LVEF and HR were higher than those of the control group, the levels of RMSSD and SDANN were lower than those in the control group, the level of SDNN was higher than that of the control group, with statistically significant differences (P<0. 05). The total effective rate of the observation group was 96. 67% (58 / 60), higher than 83. 33% (50 / 60) of the control group, the difference was statistically significant (P < 0. 05). CONCLUSIONS: Huangqi Guizhi Wuwu decoction in the treatment of patients with bradyarrhythmias can improve vascular endothelial function, inhibit inflammation, reduce myocardial damage, improve heart rate, heart rate variability and cardiac function, and improve the clinical efficacy.
- Subjects
GROWTH differentiation factors; CARDIAC patients; NOCICEPTIN; HEART beat; VASOACTIVE intestinal peptide; GROUP psychotherapy; VENTRICULAR ejection fraction
- Publication
Evaluation & Analysis of Drug-Use in Hospitals of China, 2023, Vol 23, Issue 1, p54
- ISSN
1672-2124
- Publication type
Article
- DOI
10.14009/j.issn.1672-2124.2023.01.011