We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Determination of 10 sex hormones in cosmetics by QuEChERS-UPLC.
- Authors
Bei Hu; Lixia Li; Hong Liu; Wei Huang; Xiaoping Ding
- Abstract
A method of QuEChERS coupled with ultra-high performance liquid chromatography was developed for determination of 10 sex hormones in cosmetics・ The sample was dispersed using saturated sodium chloride, and purified by QuEChERS after acetonitrile ultrasound extraction. Chromatographic separation was achieved on a CORTECS C18+ column (2.1 mm X 100 mm, 2.7) by gradient elution using acetonitrile-water as mobile phase・ PDA detector was used to test samples at multiple wavelengths, and external standard method was used for quantification. Results show that there is a good linear relationship for each of the 10 sex hormones in respective mass concentration range with their correlation coefficients (r) all above 0.99. The limits of detection (LOD) and the limits of quantitation (LOQ) for the 10 sex hormones are in the range of 0.02-0」|ig/mL and 0.05-0.3 |ig/mL, respectively. Average recoveries at three levels of 5, 25 and 50 pig/g are in the range of 81 ・2%--103・5%, with relative standard deviations (RSD, n=6) of 0・5%--12・0%・ With the advantages of simplicity and good reproducibility, this method is suitable for the analysis of sex hormones in cosmetics.
- Subjects
SEX hormones; GRADIENT elution (Chromatography); COSMETICS; LIQUID chromatography; STANDARD deviations
- Publication
China Surfactant Detergent & Cosmetics (1001-1803), 2021, Vol 51, Issue 9, p918
- ISSN
1001-1803
- Publication type
Article
- DOI
10.3969/j.issn.1001-1803.2021.09.016