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- Title
Synthesis and Antinociceptive Activity of 2-[(2-Oxobenzothiazolin-3-yl)methyl]-5- aminoalkyl/aryl-1,3,4-thiadiazole.
- Authors
Önkol, Tijen; Çakir, Bilge; Sahin, M. Fethi; Yildirim, Engin; Erol, Kevser
- Abstract
Ten 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminoalkyl/aryl-1,3,4-thiadiazole derivatives were synthesized. The chemical structures of these compounds were elucidated by their FT-IR and ¹H-NMR spectral data, as well as their elemental analyses. The compounds were tested for antinociceptive activity. Among these compounds, 2-[(2-oxobenzothiazolin-3-yl)methyl]-5-aminomethyl-1,3,4-thiadiazole (5a) was found to be significantly more active than the others and the standards in all the tests.
- Subjects
METHYL ether; ANTIDEPRESSANTS; MORPHINE; THIAZOLES; DIURETICS
- Publication
Turkish Journal of Chemistry, 2004, Vol 28, Issue 4, p461
- ISSN
1300-0527
- Publication type
Article