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- Title
Oxidative Stress and Inflammation in Retinal Degeneration.
- Authors
Jadeja, Ravirajsinh N.; Martin, Pamela M.
- Abstract
Subsequently, treatments with N-acetylcysteine (NAC) and diallyl sulfide (DAS) reduced oxidative stress and improved cell survival by modulating the upstream angiogenesis and inflammatory regulators. 1972; 76: 64-80. 5024602 6 Datta S., Cano M., Ebrahimi K., Wang L., Handa J.T. The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD. Given the abundance of clinical and experimental evidence pointing to oxidative stress as a major player in RPE damage and outer retinal dysfunction, therapeutic interventions that reduce oxidative stress in RPE cells represent a viable option to mitigate retinal degeneration. Macchioni and colleagues [[8]] created an in vitro experimental condition in which human RPE cells (ARPE-19) were exposed to 10 M H SB 2 sb O SB 2 sb (hydrogen peroxide) for several passages to mimic chronic in vivo oxidative stress conditions.
- Subjects
RETINAL degeneration; OXIDATIVE stress; MITOCHONDRIAL DNA; PATHOLOGICAL physiology; ANTERIOR eye segment; RETINAL vein occlusion; RHODOPSIN
- Publication
Antioxidants, 2021, Vol 10, Issue 5, p790
- ISSN
2076-3921
- Publication type
Editorial
- DOI
10.3390/antiox10050790