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- Title
Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery.
- Authors
Torchilin, Vladimir P.
- Abstract
The use of nanoparticulate pharmaceutical drug delivery systems (NDDSs) to enhance the in vivo effectiveness of drugs is now well established. The development of multifunctional and stimulus-sensitive NDDSs is an active area of current research. Such NDDSs can have long circulation times, target the site of the disease and enhance the intracellular delivery of a drug. This type of NDDS can also respond to local stimuli that are characteristic of the pathological site by, for example, releasing an entrapped drug or shedding a protective coating, thus facilitating the interaction between drug-loaded nanocarriers and target cells or tissues. In addition, imaging contrast moieties can be attached to these carriers to track their real-time biodistribution and accumulation in target cells or tissues. Here, I highlight recent developments with multifunctional and stimuli-sensitive NDDSs and their therapeutic potential for diseases including cancer, cardiovascular diseases and infectious diseases.
- Subjects
DRUG delivery systems; DRUG efficacy; CANCER treatment; CARDIOVASCULAR disease treatment; COMMUNICABLE disease treatment; PHARMACEUTICAL industry
- Publication
Nature Reviews Drug Discovery, 2014, Vol 13, Issue 11, p813
- ISSN
1474-1776
- Publication type
Article
- DOI
10.1038/nrd4333