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- Title
Protein conformational diseases: Rescuing protein homeostasis.
- Authors
Crunkhorn, Sarah
- Abstract
The article presents a study which investigates the proteostasis regulators that restores protein homeostasis and activates heat shock response (HSR) in protein conformational diseases. The study developed a human cell-based screen to identify activators of the HSR, where it confirmed 263 positive hits and had proteostasis regulators. Result shows that the compounds rescued cell surface expression and reduced aggregate formation of huntingtin protein of cystic fibrosis and Huntington's disease.
- Subjects
HEAT shock proteins; HOMEOSTASIS; HUMAN cell membranes; CELL receptors; HUNTINGTON disease; CYSTIC fibrosis
- Publication
Nature Reviews Drug Discovery, 2012, Vol 11, Issue 2, p105
- ISSN
1474-1776
- Publication type
journal article
- DOI
10.1038/nrd3662