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- Title
Event-related potentials following cutaneous electrical stimulation in patients with chronic whiplash associated disorders.
- Authors
Lenoir, D.; Willaert, W.; Ickmans, K.; Nijs, J.; Cagnie, B.; Meeus, M.; Vonck, K.; Delbeke, J.; De Pauw, R.; Coppieters, I.
- Abstract
Introduction: Whiplash injuries typically occur from a motor vehicle collision and lead to chronic whiplash associated disorders (CWAD) in 20-50% of cases. Changes in neurotransmission, metabolism and networks seem to play a role in the pathogenic mechanisms of CWAD. Methods: This case-control study (CWAD patients/healthy controls (HC):50/50), investigated ankle and wrist electrical pain thresholds (EPT) and the amplitude and latency of event-related potentials (ERPs) resulting from 20 electrical stimuli at the intensity of 1,4xEPT. Linear mixed effect models were applied to detect group differences in EPTs and ERP characteristics. Correlations between ERP characteristics, EPT, self-reported pain, disability, pain catastrophizing and symptoms of central sensitisation (CS) were investigated. Results: In CWAD patients, left wrist P3 latency (t = -2.283; p = 0.023) was prolonged, and their ankle EPT correlated with ankle P1 (ρs = 0.293; p = 0.044) and P3 amplitude (ρs = 0.306; p = 0.033), and left wrist P3 amplitude (ρs = 0.343; p = 0.017). Symptoms of CS correlated with right wrist P3 amplitude (ρs = 0.308; p = 0.030) and latency (ρs = -0.341; p = 0.015), and the worst pain during the week before the assessment correlated with left wrist P1 latency (ρs = 0.319; p = 0.029). Discussion: CWAD patients did not show signs of hypersensitivity, but their ERP characteristics seemed to be related to the intensity of the stimulus, self-reported symptoms of CS, and worst pain during the week before the assessment. Process evaluation: Self-reported disability had changed between time of inclusion and baseline assessment, resulting in the inclusion of 8 CWAD patients with low disability at baseline.
- Subjects
NETHERLANDS; NEURAL transmission; WHIPLASH injuries; CHRONIC diseases; CONFERENCES &; conventions; ELECTRIC stimulation; DISEASE complications
- Publication
Pain Practice, 2022, Vol 22, p14
- ISSN
1530-7085
- Publication type
Article
- DOI
10.1111/papr.13128