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- Title
Targeting the Cerebrospinal Fluid Compartment in Glaucoma: Still the Dark Side of the Moon? Comment on Passaro et al. Glaucoma as a Tauopathy—Is It the Missing Piece in the Glaucoma Puzzle? J. Clin. Med. 2023, 12, 6900.
- Authors
Wostyn, Peter
- Abstract
The article discusses the potential connection between glaucoma and tau-associated disorders, such as Alzheimer's disease (AD). The authors explore various therapeutic strategies for tauopathies and glaucoma, including targeting the cerebrospinal fluid (CSF) compartment. They discuss studies that have found structural changes in the eye that link AD and glaucoma, as well as the relationship between CSF profiles and the thickness of the lamina cribrosa in glaucoma patients. The article suggests that targeting CSF dynamics and glymphatic clearance could be new directions for glaucoma treatment. The author encourages further research in this area.
- Subjects
CEREBROSPINAL fluid; TAUOPATHIES; SUBARACHNOID space; GLAUCOMA; OPTIC nerve injuries; OPEN-angle glaucoma; AMYLOID beta-protein precursor; ALTERNATIVE RNA splicing
- Publication
Journal of Clinical Medicine, 2024, Vol 13, Issue 3, p827
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm13030827