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- Title
Development and Validation of Therapeutically Relevant Multi-Gene Biomarker Classifiers.
- Authors
Simon, Richard
- Abstract
Attempts to provide possible explanations for the inconsistency of results of a June 2004 study on a two-gene expression ratio that authors claimed accurately predicted clinical outcome of early-stage breast cancer patients treated with adjuvant tamoxifen monotherapy and a 2005 study that failed to confirm the usefulness of the two-gene expression ratio. Microarray expression profiling; Method used in the first study to develop the classification model.
- Subjects
BIOMARKERS; GENE expression; BREAST cancer; TAMOXIFEN; CANCER
- Publication
JNCI: Journal of the National Cancer Institute, 2005, Vol 97, Issue 12, p866
- ISSN
0027-8874
- Publication type
Editorial
- DOI
10.1093/jnci/dji168