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- Title
Atypical memory B-cells are associated with Plasmodium falciparum anemia through anti-phosphatidylserine antibodies.
- Authors
Rivera-Correa, Juan; Mackroth, Maria Sophia; Jacobs, Thomas; zur Wiesch, Julian Schulze; Rolling, Thierry; Rodriguez, Ana
- Abstract
Anemia is a common complication of malaria that is characterized by the loss of infected and uninfected erythrocytes. In mouse malaria models, clearance of uninfected erythrocytes is promoted by autoimmune anti-phosphatidylserine (PS) antibodies produced by T-bet+B-cells, which bind to exposed PS in erythrocytes, but the mechanism in patients is still unclear. In Plasmodium falciparum patients with anemia, we show that atypical memory FcRL5+T-bet+ B-cells are expanded and associate both with higher levels of anti-PS antibodies in plasma and with the development of anemia in these patients. No association of anti-PS antibodies or anemia with other B-cell subsets and no association of other antibody specificities with FcRL5+T-bet+ B- cells is observed, revealing high specificity in this response. We also identify FcRL5+T-bet+ B-cells as producers of anti-PS antibodies in ex vivo cultures of naıve human peripheral blood mononuclear cells (PBMC) stimulated with P.-falciparum-infected erythrocyte lysates. These data define a crucial role for atypical memory B-cells and anti-PS autoantibodies in human malarial anemia.
- Subjects
B cells; PLASMODIUM falciparum; ERYTHROCYTES; IMMUNOGLOBULINS; ANEMIA; BLOOD cells
- Publication
eLife, 2019, p1
- ISSN
2050-084X
- Publication type
Article
- DOI
10.7554/eLife.48309