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- Title
Synthesis of isotope – labeled selective PDE5 inhibitor sildenafil (UK 92480-10).
- Authors
Bolla, R. Sekhar; Gulipalli, Kali Charan; Gandikota, N. Murthy; Bodige, Srinu; Viswanath, I. V. Kasi
- Abstract
Sildenfil a vasodilating agent is a selective inhibitor of cyclic guanosine monophosphate – specific phosphodiesterase type 5 which is used for the treatment of male erectile dysfunction and pulmonary arterial hypertension. We presented a detailed approach for the synthesis of [2H3]sildenafil, [2H8]sildenafil and N-desmethyl [2H8]sildenafil. By using the approach we successfully synthesized [2H3]sildenafil, [2H8]sildenafil and N-desmethyl [2H8]sildenafil with good isotopic abundance.
- Subjects
CHEMICAL reactions; SILDENAFIL; MASS spectrometry; CRYSTAL structure; BIOCHEMISTRY
- Publication
Radiochimica Acta, 2018, Vol 106, Issue 10, p851
- ISSN
0033-8230
- Publication type
Article
- DOI
10.1515/ract-2018-2925