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- Title
Spectrophotometric determination of purine alkaloids by flow injection and sequential injection analysis.
- Authors
Shpigun, L.; Andryukhina, E.; Shushenachev, Ya.
- Abstract
Procedures are developed for the flow-injection and sequential-injection determination of purine (xanthine) alkaloids (caffeine, theophylline, theobromine, and aminophylline) based on their spectrophoto-metric detection by the oxidative coupling reaction with 3-methyl-2-benzothiazolinone hydrazone hydrochloride under the action of potassium periodate in a weakly acidic aqueous medium (pH 5-6). The analytical range is 3-500 μg/mL, and throughput is 120-180 h. It is demonstrated that the developed procedures can be used for the quality control of pharmaceutical preparations.
- Subjects
SPECTROPHOTOMETRY; PURINE alkaloids; FLOW injection analysis; SEQUENTIAL injection analysis; COUPLING reactions (Chemistry); HYDRAZONES
- Publication
Journal of Analytical Chemistry, 2015, Vol 70, Issue 8, p926
- ISSN
1061-9348
- Publication type
Article
- DOI
10.1134/S1061934815080158