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- Title
Sirolimus versus cyclosporine A in patients with primary acquired pure red cell aplasia: a prospective cohort study.
- Authors
Yang, Yuan; Tang, Zengwei; Huang, Yuzhou; Hu, Qinglin; Wang, Shuqing; Ji, Jiang; Du, Yali; Yang, Chen; Chen, Miao; Hu, Shimin; Han, Bing
- Abstract
Among them, three patients relapsed during the tapering period (0.5 mg/d): two patients responded again after the dose was increased, and the other patient did not response and remained transfusion dependent. These data, in combination with our previous data showing that the Treg levels in CsA-refractory patients increased significantly after effective salvage therapy with sirolimus [[12]], indicate that sirolimus may act differently, and it may rescue some patients resistant to CsA. 1Patient screening and assignment, and comparison of hemoglobin level, relapse-free survival or serum creatinine level in patients with sirolimus or CsA treatment.
- Subjects
PURE red cell aplasia; RAPAMYCIN; CYCLOSPORINE; LONGITUDINAL method
- Publication
Blood Cancer Journal, 2023, Vol 13, Issue 1, p1
- ISSN
2044-5385
- Publication type
Article
- DOI
10.1038/s41408-023-00845-3