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- Title
MAGE-A genes as predictors of the outcome of laryngeal squamous cell carcinoma.
- Authors
Liu, Shenghui; Zhao, Yan; Xu, Yuru; Sang, Meixiang; Zhao, Ruili; Gu, Lina; Shan, Baoen
- Abstract
Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumors in the head and neck area. Melanoma-associated antigens A (MAGE-A) are strictly tumor-specific and are expressed in several types of tumors. To date, no studies have reported the potential of MAGE-A genes as markers for circulating tumor cells (CTCs) in patients with LSCC. The present study aimed to evaluate the expression and the possible prognostic significance of MAGE-A in the peripheral blood of patients with LSCC. In the present study, the expression of MAGE-A genes was determined by multiplex semi-nested PCR and restriction endonuclease treatment of the peripheral blood of patients with LSCC. The association between MAGE-A gene expression and clinicopathological parameters and prognosis was evaluated. The results demonstrated that the expression of MAGE-A was associated with the predictors that indicate poor prognosis. The expression levels of MAGE-A and each individual MAGE-A gene were also associated with a shorter overall survival time of patients with LSCC. In conclusion, the results of the present study suggested that the expression of MAGE-A genes may be a potential prognostic marker for patients with LSCC.
- Subjects
SQUAMOUS cell carcinoma; ENDONUCLEASES; TUMOR markers; GENE expression; HEAD &; neck cancer; GENES
- Publication
Oncology Letters, 2020, Vol 20, Issue 4, pN.PAG
- ISSN
1792-1074
- Publication type
Article