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- Title
t(14;18)(q32;q21) in chronic lymphocytic leukemia patients: Report of two cases and a literature review.
- Authors
WEIFENG CHEN; YI MIAO; RONG WANG; YUJIE WU; HAIRONG QIU; WEI XU; JIANYONG LI; LEI FAN; XIN XU
- Abstract
The chromosomal abnormality t(14;18)(q32;q21) is most commonly associated with germinal center-derived B-cell lymphomas, particularly follicular lymphoma (FL). Generally, it is considered a hallmark of FL. The t(14;18)(q32;q21) translocation is rare in chronic lymphocytic leukemia (CLL) and its prognostic significance remains unclear. In the present study, two cases of CLL with t(14;18)(q32;q21) were diagnosed using conventional cytogenetic analysis and fluorescence in situ hybridization. Both patients presented with leukemia and the morphological features and immunophenotypes were typical of CLL. Case 2 underwent a further lymph node biopsy, which established a diagnosis of CD5-CLL/small lymphocyte lymphoma. In addition to t(14;18)(q32;q21), trisomy 12 was identified in the same clone in Case 2. Both cases exhibited immunoglobulin heavy chain variable mutations, and heavy-chain variable region gene (VH) 4-39 and VH3-62 were used in Case 1 and Case 2, respectively. In addition, direct Sanger sequencing of exons 4-9 revealed that Case 2 harbored the tumor protein p53 mutation, c.829T>G. Both cases had indications for therapy. Case 1 responded well to chlorambucil treatment, and was still alive at the last follow-up. Conversely, Case 2 exhibited aggressive disease that appeared refractory to treatment, and eventually succumbed to the disease.
- Subjects
IMMUNOPHENOTYPING; LYMPHOCYTIC leukemia; CYTOGENETICS; GENETIC mutation; P53 antioncogene; PROGNOSIS; PATIENTS
- Publication
Oncology Letters, 2016, Vol 12, Issue 6, p4351
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2016.5258